Restoration of intracellular acetyl-CoA by supplementing growth media with ... More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN ...

Targeting aldolase A to induce imbalanced glycolysis could overcome the intrinsic ... I in melanoma cells increases mitochondrial acetyl-CoA levels, leading to epigenetic activation of genes ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

Restoration of intracellular acetyl-CoA by supplementing growth media with ... Co-authors with Shi in the study, "HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ ...