The study of the cell cycle focuses on mechanisms that regulate the timing and frequency of DNA duplication and cell division. As a biological concept, the cell cycle is defined as the period ...

In a 2022 study in Cell Reports Medicine ... to adenine dinucleotide (NAD+), an important intermediary that fosters TCA cycle function, also improved function in their study models.

It occurs when intracellular copper binds to proteins involved in the tricarboxylic acid (TCA) cycle, leading to protein aggregation, mitochondrial dysfunction, and ultimately, cell death.