sAPPα is a secreted peptide produced from APP processing along the "non-amyloidogenic" pathway. Meta-analysis did not show a statistically significant difference in the levels of sAPPα in the plasma ...

However, while the level of Aβ42 in blood is not by itself a good biomarker for AD, the Aβ42:Aβ40 ratio has gained attention as a plasma biomarker that predicts amyloid-PET status regardless of ...