A person with neuroblastoma, which occurs when developing nerve cells in children turn cancerous, has remained tumour-free ...

Scientists engineered T cells to protect instead of kill, potentially enabling targeted treatments for autoimmune disease and ...

The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering ...

An 18-year survivor of neuroblastoma, a solid childhood tumor that develops in immature nerve cells, is believed to represent ...

在细胞工程领域，分离经过基因编辑的细胞一直是研究热点，目前已开发出多种方法。如使用表面标签和耐药盒来富集含有转基因整合的细胞，但对细胞进行多种药物处理或连续进行阳性选择会对细胞活力、性能和产量产生负面影响；靶向必需位点虽可富集转基因整合细胞，但同时编辑多个必需基因的后果尚未明确；还有研究利用在一个位点引入的选择标记来富集另一个位点的整合，但缺乏直接多标记选择的富集方法，难以获得更纯的细胞群体。