Single-cell imaging and mass spectrometry data reveal adenosine in the DNA of mammalian cells can be methylated by METTL3 to form N6-methyladenosine in response to DNA damage.

This is intriguing because the previously determined structures of uracil DNA glycosylase in complex with product DNA (Fig. 2, left panels) revealed that the abasic site sugar is also in the alpha ...

(Image: Public Domain) Uracil was first discovered in 1900 by the Italian chemist Alberto Ascoli, who isolated it from yeast nucleic acids. However, its role as a nucleobase in RNA was not established ...