The `unfolded-protein response' triggered by the presence of ... that surround the dilated ER in several different cell-culture systems, in the livers of PiZ (a mutant allele of α1-AT) transgenic ...

and mRNA breaks (during the unfolded protein response). The biochemical outcomes and end-specificities of the healing and sealing reactions they catalyze are unique compared to the tRNA repair systems ...

They are armed with a built-in protein quality control system—the mitochondrial unfolded protein response, or UPR mt —that helps them maintain function even when component proteins within get ...