A detailed quantitative model of signaling by IRE1 sheds light on the mechanism of its activation by endoplasmic reticulum stress and addresses a long-standing controversy in the field. In ...

Mitochondria play a crucial role in acquiring pluripotency and determining cell fate. The mitochondrial unfolded protein ...

a process tightly controlled by the unfolded protein response (UPR). New research published in eGastroenterology demonstrates that disruptions in the UPR contribute to inflammatory bowel diseases ...

A team of Chinese researchers led by Prof. WANG Likun from the Institute of Biophysics of the Chinese Academy of Sciences has provided new insights into metabolic disease mechanisms and potential ...

The Diehl lab also explores the interconnections of lipid signaling, epigenetic regulation and the role of the unfolded protein response within tumor progression. One major focus of Dr. Diehl’s ...

One such mutation occurs in the gene encoding FicD, an enzyme that regulates the activity of BiP, a protein that helps ... leads to the buildup of unfolded proteins inside cells, chronically ...

Research and Teaching Interests: Plant Molecular Biology, Endoplasmic Reticulum Stress and Unfolded Protein Response (UPR), Pro- and Anti-apoptotic Signaling in Plant Immunity, Plant Hormonal ...