Han, R.J. Ulevitch, R.J. Davis, "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine ... Medical ...

Signal transduction by cell adhesion receptors ... Integrin cytoplasmic tyrosine motif is required for outside-in aIIbb3 signalling and platelet function. Nature 401, 808–811 (1999).

We report here that the SLAM receptor is capable of triggering a protein tyrosine phosphorylation signal in T cells via ... the Src-related protein tyrosine kinase FynT. We also show that ...

As such, kinases are key signal transduction molecules relevant in ... content peptide microarray containing phosphorylatable tyrosine (PTK chip) or serine/threonine (STK chip) residues within kinase ...

Research in our laboratory aims to characterize the molecular mechanisms underlying cell-to-cell interactions and signal transduction across the ... Tie2 and Eph Receptor Tyrosine Kinase Activation ...

Gefitinib is supplied in 250 mg tablets; the recommended daily dose being 250 mg once daily, with or without food. The elimination half-life is 48 hours and the mean bioavailability is 60%.

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause the ... including transmembrane tyrosine kinases and steroid receptors. The ...

Cellular and molecular biology, protein tyrosine phosphorylation, pseudophosphatase roles in signal transduction, protein ... functional characteristics of the pseudophosphatase map kinase ...

Cohen, D.T. Dudley, A.R. Saltiel, "PD098059 is a specific inhibitor of mitogen-activated protein kinase kinase in vitro and in vivo ... Saltiel, department of signal transduction, Parke-Davis, Ann ...