several NCI- sponsored trials are testing drugs against signal transduction targets. One such molecule is genistein, a soy bean natural product that is a known protein-tyrosine kinase inhibitor ...

We report here that the SLAM receptor is capable of triggering a protein tyrosine phosphorylation signal in T cells via ... the Src-related protein tyrosine kinase FynT. We also show that ...

Han, R.J. Ulevitch, R.J. Davis, "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine," Journal ...

Edited by: Paul Smaglik D.R. Alessi, A. Cuenda, P. Cohen, D.T. Dudley, A.R. Saltiel, "PD098059 is a specific inhibitor of mitogen-activated protein kinase kinase in vitro and in vivo," Journal of ...

Research in our laboratory aims to characterize the molecular mechanisms underlying cell-to-cell interactions and signal transduction across the cell membrane ... and Nikolov DB, Tie2 and Eph Receptor ...

Cellular and molecular biology, protein tyrosine phosphorylation, pseudophosphatase roles in signal transduction, protein:protein interactions Year of arrival ... My lab focuses on various functional ...

The main goal of our laboratory is the identification and characterization of signal ... transmembrane tyrosine kinases and steroid receptors. The laboratory is studying the role of Hsp90 family ...

As such, kinases are key signal transduction molecules relevant in almost every cellular ... This system utilizes a high content peptide microarray containing phosphorylatable tyrosine (PTK chip) or ...