Pharmaceutical ads are difficult to avoid in American television programming and a growing number of them promote a class of ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified ... (ALCL), driving transformation through many molecular mechanisms. In this Review, we will analyse how ...

Together, these novel mechanisms of GPCR-mediated MAPK regulation ... including phospholipase Cγ and the non-receptor tyrosine kinase c-Src. EGFR activation also leads to tyrosine phosphorylation ...

Researchers at the Harvard Medical School discovered that the enzyme GUK1 promotes lung cancer growth by boosting the ...

The molecular mechanisms of action ... extracellular portion of RTKs and small-molecule inhibitors of their tyrosine kinase activity are strategies in more advanced phases of clinical development.

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...

Cellular and molecular biology, protein tyrosine phosphorylation, pseudophosphatase roles in signal transduction ... My lab focuses on various functional characteristics of the pseudophosphatase map ...

Company Poised to Enter Booming Bispecific Antibody Market Amid Growing Pharma Interest Providence, RI, Feb. 10, 2025 (GLOBE NEWSWIRE) -- (NASDAQ: OCEA) today announced newly published research ...