Notch has two faces; one that promotes and the other that suppresses tumorigenesis. Which of the two faces is shown is dependent on the cellular context and the crosstalk with other signal ...

Since these ES cells contain the exon 11 deletion found in mice that conditionally develop mammary gland tumors, the homologous repair defect is, thus far, found to correlate with tumorigenesis.

Cellular senescence (CS) marks a crucial cell cycle halt triggered in proliferating cells under various stress conditions, manifesting across different ...

Recent research has highlighted the crucial role of circadian rhythms in tumor biology, demonstrating that their dysregulation contributes to tumorigenesis, progression, and metastasis.

The Wistar Institute's Paul M. Lieberman, Ph.D. and lab identified and tested a new method for targeting certain cancers caused by Epstein-Barr Virus (EBV), in the paper, "USP7 inhibitors destabilize ...

Genetic mutations in FGFR2 drive tumorigenesis, particularly in endometrial cancer, but Ding’s evidence shows that epigenetic modifications similarly promote oncogenesis. “We’re very excited about ...

Circadian rhythms are endogenous time-keeping mechanisms that regulate physiological processes in response to external light-dark cycles. These ...