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天然产物 Hdy-7 靶向 TrxR1/2调控溶酶体生成抑制癌细胞生长
研究人员开展天然产物 Hdy-7 相关研究,发现其靶向 TrxR 1/2 诱导 ROS 介导的溶酶体生成,抑制癌细胞生长。 溶酶体已从主要的降解场所转变为细胞内稳态的动态调节者。氧化还原环境改变的癌细胞可作为癌症治疗的潜在靶点。包含硫氧还蛋白还原酶(TrxRs ...
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