A century after Down syndrome was first described, scientists discovered that the root cause of this disorder is a condition called trisomy 21. What strides in research have been made since then?

What is the structure of a chromosome? Why does the total number of chromosomes in a cell matter? Learn how chromosomes self-organize within single cells, and how these patterns help us detect ...

The genetic condition, known as Trisomy 21, results in an extra copy of chromosome 21. A video shared on Instagram by the Rangers shows Burger talking about what the number switch means to him.

Decades of tests had shown that she had both Down syndrome and an intermediate level of Alzheimer's. Physical examinations ...

Down Syndrome, known as Trisomy 21, is a genetic disorder caused by an extra chromosome 21. It affects facial appearance, ...

FOR TOO long, Black children with Down syndrome (Trisomy 21) have been invisible, absent from mainstream representation, ...

Ryotaro Hashizume and colleagues use the CRISPR-Cas9 gene editing system to cleave the third chromosome in previously generated trisomy 21 cell lines derived from both pluripotent cells and skin ...

2020). Most commonly, trisomy 21 arises because of meiotic nondisjunction in which a pair of chromosomes 21 fail to separate in either the sperm or egg. The frequency of this alteration is relatively ...

More information: Ryotaro Hashizume et al, Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells, PNAS Nexus (2025). DOI: 10.1093/pnasnexus/pgaf022 ...

Genome-wide effects of trisomy 21; RNA-based signs of transgenerational stress; depression and resilience; a call to overhaul US biomedical research system A series of rodent experiments showed that ...