The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...

These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

Insights into the structures could lead to improved treatment strategies for transthyretin amyloidosis, a progressive, fatal disease in men.

The work highlights the utility of cryo-EM in studying small proteins and uncovering targets for structure-based drug design in transthyretin amyloidosis. Toxic protein aggregation is a hallmark ...

UAB researchers reveal how managing cardiovascular risk factors can mitigate heart failure risk in Black individuals carrying the transthyretin V142I genetic variant. Some 3 percent to 4 percent of ...

Scripps Research scientists discovered that some sections of the hormone-carrying molecule transthyretin (left) are in constant motion (right), which may explain why the protein can misfold and ...

Here, the authors explore how composition and structure of protein aggregates affect dormancy and exit from this state. Cryo-EM reveals how transthyretin moves, offering insights into ligand ...