Therefore, we set out to investigate alternative balancing mechanisms, whose induction must occur faster than transcriptional regulation. An unanswered, but intriguing question, concerns the ...

In the default model, the graph representing each individual enhancer can be arbitrarily complicated. To show how the ABC Score formula can arise from the default model, we need to impose the further ...

Liver cancer poses significant challenges due to its complex causes and resistance to conventional treatments, highlighting the need for innovative ...

The Neilson Laboratory studies post-transcriptional regulation of gene expression in human diseases. This is an explanation of what that is and why we do it. The explosion of publicly available ...

Mitochondria play a crucial role in acquiring pluripotency and determining cell fate. The mitochondrial unfolded protein ...

We study how the transcriptional networks are rewired in cancer cells, and how this rewiring could be exploited as cancer therapy. The major disease model of interest is prostate cancer, and ...

In experiments where transcriptional activation was blocked ... "Our findings highlight an unexpected link between gene ...

The researchers then evaluated the similarities between the TC and LE regions from the 12 patient tissue sections in terms of their transcriptional profiles. They found that gene expression was highly ...