We take advantage of high-throughput sequencing approaches to investigate the mechanisms that control genome-wide programs of mixed transcriptional responses (i.e. activation and repression). Most ...

The goal of this line of research is to investigate the assembly mechanism, dynamics, and heterogeneity of human transcription factor/DNA complexes, and how these parameters contribute to ...

A combination of mechanisms is responsible for the seemingly endless possibilities regarding the regulation of transcription in a gene-specific and tissue-specific manner. DNA in the eukaryotic ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...

A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation ...

Single-molecule Biochemistry and Biophysics. Transcription and RNA processing. Cytoskeletal networks and regulation. Living cells are chock full of dynamic complexes of protein, RNA, and DNA molecules ...

A new study shows that refining both transcriptions and translations using large language models leads to better speech ...

In addition, as NRTIs lack a 3'-hydroxyl group, they function as a chain terminator and inhibit reverse transcription. NRTI-resistance mutations & their mechanism of drug resistance M184V/I is the ...