Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo.I suggest that ∼ 90% of Pol II initiation events in ...

Enzymes called RNA polymerases transcribe DNA into RNA. RNA is the intermediary that carries the information contained within DNA to the ribosomes, where the genetic information is synthesized into ...

DGRs are able to reverse-transcribe RNA back to DNA in a form of natural gene-editing. This process accelerates the evolution of proteins to help microorganisms adapt to changing environments.

Cell-free, in vitro protein expression is a welcome alternative to time-consuming cell-based systems and appeals to scientists interested in toxic, insoluble, or rapidly degraded proteins incompatible ...

RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...

Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., diversity ...