To understand biological systems at a functional level, a comprehensive picture of the diverse forms proteins can take is crucial. Top-down mass spectrometry (MS)-based proteomics provides a ...

MS, an experimental protocol combining high-resolution protein fractionation using SDS-polyacrylamide gel electrophoresis (SDS-PAGE) with the latest mass spectrometry technology to enable highly ...

a newer approach of analyzing intact proteoforms by LC-MS is called top-down proteomics. Along the lines of the Human Genome Project that mapped all of our genes, there have been attempts to build ...

We specialize in high throughput top down liquid chromatography-mass spectrometry. This allows us to study chromatin biology with proteoform level specificity and observe quantitative changes to ...

Exosomes, the small extracellular vesicles secreted by nearly all cell types, have emerged as powerful players in intercellular communication and potential biomarkers for disease diagnosis and therapy ...

Proteomics is the large-scale study of proteins, particularly their structures and functions. It involves the systematic identification, quantification, and analysis of the entire protein complement ...

They then used proteomics to identify these proteins and narrow down which ones were potentially involved in the process. The ...