there was concern about what’s called C cell tumors, which are very specific and rare types of thyroid cancer, being found in rats. And because this was observed in rats, when the very first GLP ...

Studies of thyroid cancer cell lines suggest that an imbalance between the two estrogen receptor (ER) isoforms, α and β, may be responsible for the cell proliferation seen with estrogen treatment.

Such a morphologically distinct cell type has been assumed to have a function distinct from that of the follicular cell, that is, the production of iodine-containing thyroid hormones.