Regardless, the association between increased levels of methylated thiopurine metabolites and adverse events of all types is an important one, as the most striking effect in previous studies has ...

Thiopurine metabolism and thiopurine methyl transferase (TPMT) enzyme activity assay. Azathioprine (AZA) is converted into 6-mercaptopurine (6-MP), which can also be administered as a parent drug.

One of the key areas of research has been the identification of genetic polymorphisms that affect thiopurine metabolism. For instance, variations in the TPMT gene can lead to different levels of ...

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of ...

Metabolite monitoring; NNT: Number needed to treat; QALY: Quality-adjusted life year; TPMT: Thiopurine S-methyltransferase. Disclosure: The authors have no other relevant affiliations or financial ...