Guarding genes against damage is a crucial and complex job, so it’s to be expected that cells have several mechanisms to repair DNA breakages, each providing support under different circumstances.

Various intermediates in the base excision repair (BER) of a DNA base lesion (Adduct, ) are illustrated, including: an uncleaved AP site (AP site, ), a 5′-uncleaved AP site (Nicked DNA with dRP ...

To maintain the integrity of the genetic information, cells have evolved various DNA repair mechanisms. These mechanisms can detect and correct different types of DNA damage, such as base mismatches, ...

PARylation is integral to many key cellular functions, including signaling modulation and DNA repair. PARylation is reversible and is undone by PAR erasers such as poly ADP-ribose glycohydrolase (PARG ...

Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases. (Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base ...

Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena have discovered a new function of the DNA repair protein ATR in regulating mitochondrial homeostasis.

Prostate cancer is the most common cancer in men worldwide. Thanks to scientific breakthroughs, there are more ways than ever to treat it — especially when it’s caught early. One ...