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生物通
8 天
用人类调节序列修饰端粒酶基因将小鼠端粒重置为人类长度
然而,在哺乳动物物种之间,端粒酶的调控和端粒长度存在显著差异。在人类中,端粒酶的表达局限于少数器官,如睾丸、卵巢和胸腺,许多老化组织中的端粒会逐渐耗尽。但对 60 多种哺乳动物的比较研究发现,包括小鼠在内的许多生物并没有端粒介导的复制性衰老现象。小鼠的端粒酶表达限制较少,大多数组织都能表达较高水平的 Tert mRNA 和端粒酶活性。实验室内的近交系小鼠,如 ...
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