The analysis of the involvement of crisis in tumorigenesis has been aided by genetically defined cancer-prone mice that lack telomerase activity. These mouse models have provided insights into the ...

In most cancers, however, telomerase is again turned on and aids proliferation. The mutations In 2013, researchers found two mutations in the TERT promoter that occur frequently in cancer cell lines ...

Telomerase is a ribonucleoprotein enzyme responsible for maintaining telomere ... Lacks well-eastablished analytical tools Researchers have observed that mutations in the TERT promoter elevate cancer ...