Figure 1: Expression of WT-hTERT and DN-TERT in immortalized ... catalytic subunit of telomerase, hTERT, results in telomere loss and limits the growth of several human cancer cell lines.

In most cancers, however, telomerase is again turned on and aids proliferation. The mutations In 2013, researchers found two mutations in the TERT promoter that occur frequently in cancer cell lines ...

heart disease and cancer. The study, published today in Cell, identified a small molecule compound that restores ...

Telomerase reverse transcriptase (TERT) promotes the expression of the enzyme telomerase, which is responsible for copying the ends of chromosomes known as telomeres. Maintaining telomere length is ...