此前的研究显示，ALS和FTD通常是由能够直接或间接影响TDP-43的核功能的遗传变异驱动的，而AD患者中也发现过类似于FTD的神经元TDP-43病理。再加上TDP ...

New research examining the skeletal muscle cells of patients with inclusion body myositis (IBM) has revealed that the nucleic acid-binding protein TDP-43, which is normally restricted to the ...

A team of researchers has developed a laboratory model that recapitulates the pathological aggregation of TAR DNA-binding protein 43 (TDP-43), a hallmark of amyotrophic lateral sclerosis (ALS) and ...

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a study published in Neuron, researchers report 'seeding' this accumulation through fragments of the ...

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, researchers report 'seeding' this accumulation through fragments of the ...