T cells use T cell receptors (TCRs) to identify and eliminate diseased cells. T cells equipped with cancer-targeting TCRs can detect and eliminate cancer cells, and TCR-based T cell therapies have ...

sustained expression of inhibitory receptors, impaired proliferation, and compromised mitochondrial respiration and glycolysis capacity. T cell exhaustion is a critical obstacle to the efficacy of ...

However, T cell exhaustion is a problem in the treatment of cancer, as therapeutic measures may no longer be effective. Until now, it was assumed that the body only produces such T cells in severe ...

Dysregulated expression of co-inhibitory receptors on CD4+ T cells promotes autoimmunity while sustained overexpression on CD8+ T cells promotes T cell dysfunction or exhaustion, leading to impaired ...

"Much effort in the field of immuno-oncology has involved the study of combination therapies, including combinations involving blockade of more than one T cell inhibitory receptor." Read the full ...