Recent work has shown us that G3BP nucleation of stress granules in the absence of virus infection activates PKR, resulting in phosphorylation of eIF2alpha and activation of NF-kB and JNK signal ...

The researchers found that the ZO-1 protein directs YB-1 to form beneficial stress granules. Stress granules are clusters of proteins that assemble inside cells exposed to stressful conditions ...

We are interested in mechanisms that regulate RNA Stress Granule (SG) and Processing Body (P-body) formation in cells. These two types of RNA granules aggregate translationally-silenced mRNAs and ...

Fewer stress granules (yellow) occur in cancer cells lacking G3BP1 (right) than in controls (left). Nuclei are labeled blue. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy ...

This is a 3D projection showing TIA+ stress granules in cytoplasm (relatively large yellow structures outside of nucleus (in blue)). Disclaimer: AAAS and EurekAlert! are not responsible for the ...

One of the virus's proteins binds to G3BP and prevents the formation of so-called stress granules, which would otherwise have an antiviral effect. "Our research shows that SARS-CoV-2 reprograms ...

This overactivity leads to formation of stress granules containing TDP-43, whose buildup is a factor in neuronal degeneration. Preclinical data demonstrated that ISR inhibition by DNL343 dissolves ...