TNF-α is a potent inducer of the inflammatory response, a key regulator of innate immunity and plays an important role in the regulation of Th1 immune responses against intracellular bacteria and ...

Since the validation of anti-TNF therapy for the treatment of RA, much effort has gone into making small-molecule inhibitors that lack the cost and adverse effects associated with current large ...

Image Credit: Sino Biological Inc. Disturbance in levels of the key pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF-α, and anti-inflammatory cytokines, such as IL-10, IL-4, and TGF-β ...

You have full access to this article via your institution. The isolation and identification of the TNF and lymphotoxin proteins and, especially, the availability of recombinant TNF protein ...

The structure of CD95 suggested that it belonged to the tumour necrosis factor (TNF) receptor family and that there should also be a natural ligand that was similar to TNF. A fortuitous ...

TNF Pharmaceuticals, Inc. operates as a clinical-stage pharmaceutical company, which engages in the development of drug products to extend healthy lifespan. It focuses on developing two novel ...