One such medication is spironolactone, a water pill commonly prescribed to treat conditions like high blood pressure and heart failure that has a number of off-label uses. These include managing ...

The landmark Randomized Aldactone Evaluation Study (RALES), published in 1999, showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure.

investigated whether adding the aldosterone receptor antagonist spironolactone to renin–angiotensin system inhibition improved proteinuria in patients with diabetic nephropathy. Patients with ...

adding that spironolactone users in the study were mostly diagnosed with acne (55.5%), followed by hirsutism (8.3%), and polycystic ovary syndrome (8.1%) -- all off-label uses. Spironolactone is ...