The prescribed dosage for spironolactone oral tablet may depend on your treatment plan. Other factors, including your specific diagnosis and medical history, may affect your dosage of spironolactone.

The landmark Randomized Aldactone Evaluation Study (RALES), published in 1999, showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure.

investigated whether adding the aldosterone receptor antagonist spironolactone to renin–angiotensin system inhibition improved proteinuria in patients with diabetic nephropathy. Patients with ...