Spironolactone is a medication usually used for fluid retention ... However, they might recommend starting with 25 mg a day and slowly increasing your dose to reduce your risk of side effects.

Spironolactone was initiated at a dose of 25 mg daily at the first ambulatory blood pressure monitoring and titrated to 50 mg or 100 mg daily after office-based assessment of blood pressure at ...

investigated whether adding the aldosterone receptor antagonist spironolactone to renin ... they add that the initial daily dose should be ≤25 mg to reduce the risk of hyperkalemia.

Jolly suggested that a more tolerable drug, perhaps finerenone (Kerendia ... counted the 7,062 patients randomized to spironolactone 25 mg once daily versus placebo within 72 hours following ...