Spironolactone was initiated at a dose of 25 mg daily at the first ambulatory blood pressure monitoring and titrated to 50 mg or 100 mg daily after office-based assessment of blood pressure at ...

25–50 mg daily for 1 year. Five patients taking spironolactone and one patient on placebo developed hyperkalemia within 2–12 weeks of initiation of study medication and were excluded.

while the heart failure dosage is set at 25 mg once daily. Spironolactone's established safety risks include hyperkalemia, ...

It has some similarities to the potassium-sparing diuretic spironolactone ... treatment is initiated at 25 mg once daily and titrated to a target of 50 mg once daily within 4 weeks.