Spironolactone is a medication usually ... a doctor typically prescribes a daily dose of 100 to 200 milligrams (mg). However, they might recommend starting with 25 mg a day and slowly increasing ...
25–50 mg daily for 1 year. Five patients taking spironolactone and one patient on placebo developed hyperkalemia within 2–12 weeks of initiation of study medication and were excluded.