ATLANTA — The US Institute of Medicine (IOM) is looking into whether polio vaccines contaminated with the simian virus SV40 — thought to inactivate p53 and Rb — and given 40 years ago have caused a ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.