编辑推荐：肺动脉高压(PAH)是一种以肺血管重塑为特征的致命性疾病，BMPR2信号通路异常是其关键病理机制。山东第一医科大学附属山东省立医院团队发现Sonic hedgehog(SHH)信号在PAH中异常激活，通过实验证实SHH抑制剂环巴胺(Cy)能显著改善MCT诱导的PAH大鼠血流动力学 ...

Figure 1: The Sonic hedgehog (Shh) signaling cascade is important in ... “The search is really on for additional ways to target the pathway.” Several groups have made progress in finding ...

Several components of the hedgehog (Hh) pathway are crucial to basal cell ... The requirement for canonical Wnt/β-catenin signaling in Hh-driven BCC development is increasingly recognized.