A recent paper in Nature sheds welcome light on the mechanism of somatic hypermutation by documenting the participation of double-strand DNA breaks. The antibody response, which occurs in ...

This repository supports the publication "Antibody affinity birth through somatic hypermutation" 1. It contains raw FASTA files, Python scripts, intermediate results, and results used in the analysis ...

Activation-induced cytidine deaminase (AID) plays a crucial role in the immune system by facilitating somatic hypermutation (SHM) and class switch recombination (CSR) in B cells. These processes ...

"This effect is based on a step in antibody maturation called somatic hypermutation," says Dr. Matthias Bruhn, first author of the study and postdoctoral researcher at the Institute for ...

Abstract: Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic hypermutation and subsequent preferential selection of those B cells that express B cell ...

These modules encompass diverse functionalities such as diversity analysis, statistics on V/J gene usage, distribution of conserved motifs, construction of phylogenetic trees, and analysis of affinity ...

He is known particularly for the discovery of the recombination activating genes, RAG1 and RAG2, and for insights into the biochemical function, regulation, and evolution of the RAG proteins and the ...

Noteworthy, human leucocyte antigen class II shared epitope (HLA-SE) alleles associated with the presence of V-domain glycans on ACPA-IgG. Conclusion Our observations indicate that somatic ...

Big Data,Computation Time,Differential Evolution,Differential Evolution Algorithm,Electrical Activity,Optimization Problem,Single Object,True Signal,Vector Of Size,Affinity Maturation,Amount Of Charge ...

The BCR IGH is coded for by multiple genes, including VDJ genes. Only productive and functional IG rearrangements are retained in B-cells. IGH gene rearrangements in B-cells undergo additional somatic ...