On the left, it is the schematic of porous ... of CAR T cell within the tumor bed after surgery. On the right, it is the distribution of CAR T cells (red) in the solid tumor with porous ...
Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors and were among the first solid tumor types for which such a novel treatment (in this case imatinib) became available. The ...
We used a unique 3D microfluidic model of tumors to investigate the mechanisms of treatment resistance to CAR-T cells that were designed to target B7-H3, a common antigen in solid tumor cancers.