their assembly depends on dedicated chaperones such as Sec1/Munc18 (SM) proteins. Our team has conducted the first genome-wide CRISPR screens to systematically identify new regulators of regulated ...

"I work on a specific protein called SNAP-25," says Bhasne. "Without SNAP-25, the SNARE complex, which is responsible for guiding the synaptic vesicle to the right docking points on the ...

Similarly, SPPL2a and SPPL2b have been implicated in the regulation of SNARE proteins, which are essential for membrane fusion events. These proteases were found to cleave specific SNARE proteins ...