San Francisco 49ers offensive lineman Isaac Alarcon will miss the start of the 2025 season after violating the NFL’s policy on performance-enhancing substances.

After shedding big names this offseason, the 49ers land replacements at receiver, corner and O-line. Then they add a QB for ...

San Francisco won just once in the NFC West (1-5), and went 4-8 in the NFC as a whole. The 49ers picked up two wins in one-possession games (2-6), and one in games decided by three points or fewer ...

Okuayinonu signed his one-year exclusive rights tendered contract with the 49ers on Wednesday. Okuayinonu logged a career year with San Francisco in 2024, suiting up for 16 regular-season games ...

Brock Purdy is extension-eligible, but Rams star WR Puka Nacua has a warning for the 49ers regarding the quarterback's next contract.

San Francisco 49ers practice squad offensive lineman Isaac Alarcon has been suspended for the first six games of the upcoming season for violating the NFL's policy on performance-enhancing substances.

The 49ers' tackle future is murky as Trent Williams hits his age-37 season and Colton McKivitz hits free agency in 2026.

San Francisco 49ers offensive lineman Isaac Alarcón has ... training camp and preseason games before the suspension takes effect. Alarcón (6-foot-7, 320 pounds) never has appeared in an NFL ...

History tells us the San Francisco 49ers may be in line to draft a Hall of Famer with their 1st-round pick in this year's ...

The NFL has suspended San Francisco 49ers offensive lineman Isaac Alarcón for six games without pay for violating the league's policy on performance-enhancing substances. The NFL announced a six ...