They found that reactive oxygen species (ROS) were produced by mitochondria in senescent cells. This ROS boost caused telomere shortening, a hallmark of cellular senescence; conversely, reducing ROS ...

In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...

cellular senescence and deregulated nutrient sensing contribute to excessive ROS production and are common to both peripheral and cerebral vascular dysfunction. Therefore, targeting these ...