New technology and better computational techniques allowed the team to refine its images, until it became clear that there was indeed a tRNA molecule sitting in that cavity, which is known as the ...

Several recently reported structures reveal the details of ribosome architecture and provide new insights into the mechanism of protein synthesis. Although high quality diffracting crystals of the ...

Proteins form the structural and functional backbone of the cell, and any perturbation in their synthesis can disrupt normal cellular functions. The DNA blueprint is carefully read, transcribed, and ...

Lasso peptides are made naturally using the cell’s protein-synthesis machinery, the ribosome, and are modified after assembly by a process termed post-translational modification. In this case ...

The process of translation by ribosomes, which functions as a factory of protein synthesis, may be impeded by ‘ribosome arrest peptides’ (RAPs). However, underlying mechanisms remain elusive.

The large subunit rRNA, in particular, is responsible for the peptidyl transferase reaction, which catalyzes the formation of peptide bonds between amino acids during protein synthesis. This discovery ...

acting out the various macromolecules involved in protein synthesis. Two groups form the subunits of the ribosome, a chain of ballon-headed students act as the messenger RNA (mRNA) that codes for ...

This process of protein synthesis occurs in two stages - transcription ... mRNA is now ready to leave the nucleus and travel to the ribosome. After translation, the polypeptide is finally folded ...

What is it? As the name suggests, nonribosomal peptide synthesis (NRPS) generates polypeptides sans ribosome. The resultant peptides, generally short oligomers of two to perhaps 48 residues, are not ...

Most of these antibiotics are produced outside the ribosome, the cellular structure responsible for protein synthesis, by specialized peptide synthetases encoded in the genomes of antibiotic ...