A 5.5 Å electron density map of ribonuclease has been obtained by X-ray diffraction using five isomorphous derivatives. One of the cystine residues is identified by means of a chemically modified ...

But most scientists would agree that the seed of the protein-folding problem was planted in the field of protein biology when biochemist Christian Anfinsen won the Nobel Prize in Chemistry in 1972 ...

The physiological function of this much studied pancreatic enzyme has been misunderstood. It is essential only in ruminants and certain other herbivores, where it has a special function.