This damage can lead to mutations and errors in DNA replication, thus contributing to accelerated aging and the onset of diseases. Stress-induced DNA damage can also activate signaling pathways that ...

Remarkably, we found that the typhoid toxin hijacks this RPA mechanism to induce DNA replication stress and senescence. By inducing ssDNA breaks, toxin nuclease activity sequesters RPA and exhausts ...

Although replication stress can lead to DNA damage, cell cycle arrest, interferon (IFN) signaling, and senescence or cell death, some cancer cells can evolve to tolerate this stress, thereby ...

Thus, magnesium plays a crucial role in the DNA replication process and ... antioxidant enzyme activity. Cellular senescence is associated with cellular stress and irreversible DNA damage.