How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

Although replication stress can lead to DNA damage, cell cycle arrest, interferon (IFN) signaling, and senescence or cell death, some cancer cells can evolve to tolerate this stress, thereby ...

ES cells proliferate rapidly and have been thought to experience high levels of intrinsic replication stress. However ... replication completion and cell cycle progression. Dr.

Aneuploidy is frequent in cancer, but in vitro it triggers multiple cellular stresses and often delays proliferation. Through ...

The S phase checkpoint is a kinase signaling cascade that is activated in response to DNA damage or fork stalling during replication stress. Checkpoint activation results in the stabilization ... of ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of ...

Thus, magnesium plays a crucial role in the DNA replication process and ... reduced protection against oxidative stress damage, cellular viability, cell cycle progression, and enhanced risk ...