Renal hypoplasia, defined as abnormally small kidneys with normal morphology and reduced nephron number, is a common cause of pediatric renal failure and adult-onset disease. Genetic studies ...

Transform your drug development pipeline with Newcells’ Renal Proximal Tubule Cells Model eBook. This eBook provides insight into the science behind aProximate ™, an innovative proximal tubule ...

Each kidney contains over one million microscopic filtering units called nephrons. Each nephron is made of a tubule and is responsible for 'cleaning' the blood by removing urea and excess water ...

Detection of proximal tubule injury might ... to detect injury to specific nephron segments affected by various nephrotoxicants. Histopathological changes in the kidney are associated with drug ...

(a) Kidney organoids with nephron structure scalable produced in UniMat. (b) Kidney organoid with vascular structures. (c) Establishment of polycistic kidney disease (PKD) and drug testing models ...

by inhibiting the sodium/chloride cotransporter located in the distal convoluted tubule of a nephron (the functional unit of ...