Intracellular kinases play a ubiquitous role in signaling pathways within cells. Receptor tyrosine kinases function at the beginning of a number of signal transduction cascades, whereas ...

Figure 1: a, Sequence alignment of SAM domains from the Eph family of receptor tyrosine kinases and selected ... other protein interaction modules with signaling functions such as SH3, SH2 ...

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of ... We are also actively investigating the ...

“Signaling by Receptor Tyrosine Kinases” edited by Joseph Schlessinger and Mark A. Lemmon, Cold Spring Harbor Laboratory Press, ISBN978-1-936113-33-0, pages 287-303, (2014). Xu K, Tzvetkova-Robev D, ...

RLK is structurally similar to receptor-tyrosine kinases (RTKs ... activating downstream signaling cascades, leading to the ...

Sorafenib is an oral multikinase inhibitor that inhibits tumor growth and proliferation by interfering with several receptor tyrosine kinases involved in the pathogenesis and perpetuation of ...