Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... in the activation of several downstream pathways that are shared with other tyrosine kinases. Many of these pathways have already ...

Cells have proteins called receptors ... these pathways. For instance, a single second messenger or protein kinase might play a role in more than one pathway. Through this network of signaling ...

In the bacterial chemosensory pathway ... membrane-bound, signaling array. Specific goals include elucidation of the mechanisms by which attractant and adaptation signals are transmitted through the ...

Tyrosine kinases are important elements of signal transduction pathways that transmit ... are the mutations detected in the kinase growth factor receptors Kit, Fms, or FLT3. Also, these mutations ...

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 ... identified a novel signaling pathway involving ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...