Nature11 个月
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases
Other members of the Ras superfamily, such as Rho, Rab and Ran proteins, are regulated by similar interactions with nucleotides. However, they interact with distinct regulators and downstream ...
The New England Journal of Medicine29 天
KRAS Oncoprotein Signaling in Cancer
Key among these is the activation of signaling by RHO (another member of the RAS superfamily) and the up-regulation of kinases, some of which have the same substrates as ERK. Studies are needed to ...