indicating that it is not a cell-intrinsic mechanism but delivery of rapamycin to tumour cells that is impaired in some patients. As mTOR inhibitors can inhibit a negative feedback loop that ...

The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...

But now Bowen Tan, Kristina Hedbacker, and other researchers in Friedman's Laboratory of Molecular Genetics have discovered a neural mechanism ... mTOR (short for "mammalian target of rapamycin").

This graphic outlines the mechanism of action of rapamycin in its ability to mimic dietary restriction and slow the aging process. Disclaimer: AAAS and EurekAlert! are not responsible for the ...