In yeast, the Exocyst complex and the GTPase Sec4 interact genetically with actin, profilin, Myo2 (a type-V myosin motor) and Smy1 (a kinesin-like protein) (reviewed in ref. 43). Sec4, a Rab ...

This research discovers a previously unknown mechanism that deploys a PRA-Rab protein-delivering hub to ensure ETI, linking the membrane trafficking machinery with NLR function and immune ...

Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...