在前列腺癌的研究领域，美国杜克大学医学院杜克癌症研究所前列腺与泌尿系统癌症中心的 Muthana Al Abo 等研究人员取得了一项重要进展。他们的研究成果《Genetic ancestry concordant RNA splicing in prostate cancer involves oncogenic genes and associates with recurrence》发表于 ...

we strive to understand the fundamental questions of how RNA regulation controls cellular processes in normal biology and in the context of cancer. Working at the interface of RNA splicing and breast ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

A kidney cancer cell nucleus is studded with aberrant nuclear speckles (orange). Normal healthy cells tend to have the speckles clustered toward the middle. Image credit: Kate Alexander (Cold Spring ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

For example, the Krainer lab recently investigated RNA splicing in pancreatic cancer. "Our new study provides insights into the action and specificity of splice-modifying drugs," Krainer says.

In this webinar, Dr. Megan L Noonan will present her research on the role of alternative splicing in kidney disease progression, discussing how she used nanopore RNA sequencing to accurately detect ...